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Genetic mutations may determine which ovarian cancer patients do better following HIPEC

Pancreatic cancer that has spread to the lining of the abdomen (called the peritoneum) is often difficult to treat and is associated with poor outcomes. Standard treatment typically involves chemotherapy, but survival rates remain low. Researchers conducted a systematic review to examine whether a treatment approach called cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) may improve outcomes for some patients with pancreatic cance

Peritoneal metastases occur when cancer spreads to the lining of the abdomen (the peritoneum). This can happen with cancers such as colorectal, appendiceal, gastric (stomach), ovarian cancers, and peritoneal mesothelioma. Historically, patients with peritoneal metastases had very limited treatment options and poor survival. Researchers reviewed published studies to better understand how a treatment called cytoreductive surgery combined with HIPEC affected survival.

Framarini M, D'Acapito F, Lippolis PV, Di Giorgio A, Di Pietrantonio D, Sommariva A, Sammartino P. Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies. World J Clin Oncol 2025; 16(12): 112443 [PMID: 41480175 DOI: 10.5306/wjco.v16.i12.11244 3] Peritoneal metastasis is when cancer cells spread from the stomach or other organs to the lining of the abdominal cavity. This type of sprea

This research study explored outcomes for people with colorectal cancer that had spread to two places at the same time: the lining of the abdomen (called the peritoneum), and the liver.